APITOXIN
Bee venom
Bee venom of the honeybee Apis mellifera consists of diverse substances protecting them from their natural enemies. It is a colorless slightly acidic (pH 4.5 – 5.5) liquid drying instantaneous at room temperature. Since bee venom has long been known to have anti-inflammatory effects, it has been used in unfractionated form to treat skin irritations and numerous chronic diseases for quite some time. This natural product contains an extremely complex mixture of up to 102 compounds.
The apitoxin is obtained by triggering the bees to sting through a membrane by means of an electrical stimulus. For this, voltage loaded plates are fixed in front of the entrance of the beehive or directly in the beehive. A plate underneath catches the venom which then are dried and processed further. This method is delicate. There is no death of the bees when stinging through the membrane.
It is an immemorial and generally accepted fact that bee stings have a positive effect on numerous complaints, but above all on rheumatic diseases. Already at the time of Hippocrates there are reports in which the term apitherapy arises and a medication with bee venom is told.
In general, bee venom has anti-inflammatory properties, encourage skin protection, and is used in diverse medications for chronic diseases such as multiple sclerosis.
We only market bee venom from assuredly apiarists in Europe. We offer raw and lyophilized bee venom in pharmaceutical and cosmetic grades.
MELITTIN
Peptide
Melittin is the main component of the bee venom of the honeybee Apis mellifera with a dry matter accounting of up to 65%.
The biologically active melittin consisting of 26 amino acids (Gly-Ile-Gly-Ala-Val-Leu-Lys-Val-Leu-Thr-Thr-Gly-Leu-Pro-Ala-Leu-Ile-Ser-Trp-Ile-Lys-Arg-Lys-Arg-Gln-Gln) is present in the venom reservoir in an inactive tetrameric form. It has a significant anti-inflammatory, antibacterial, antifungal, and antiviral effects. It belongs to the antimicrobial peptides enjoying further application. Besides to the pharmaceutical industry, it is also used in the health and cosmetic field. Current research shows that it can also be used in fighting tumors and cancers.
Melittin can be attained in three ways: One way is by isolating it from the natural product bee venom, the next way is the recombinant production with the help of microorganism. The chemical synthesis is another costly alternative. We offer naturally isolated melittin made from bee venom that is accomplished in our own laboratory using an effective method what we have developed ourselves. Please inform us of your requirements.
The melittin which we put up shows a purity over 95% and is almost completely separated from the allergens PLA2 and hyaluronidase.
MELITTIN
Peptide
Melittin is the main component of the bee venom of the honeybee Apis mellifera with a dry matter accounting of up to 65%.
The biologically active melittin consisting of 26 amino acids (Gly-Ile-Gly-Ala-Val-Leu-Lys-Val-Leu-Thr-Thr-Gly-Leu-Pro-Ala-Leu-Ile-Ser-Trp-Ile-Lys-Arg-Lys-Arg-Gln-Gln) is present in the venom reservoir in an inactive tetrameric form. It has a significant anti-inflammatory, antibacterial, antifungal, and antiviral effects. It belongs to the antimicrobial peptides enjoying further application. Besides to the pharmaceutical industry, it is also used in the health and cosmetic field. Current research shows that it can also be used in fighting tumors and cancers.
Melittin can be attained in three ways: One way is by isolating it from the natural product bee venom, the next way is the recombinant production with the help of microorganism. The chemical synthesis is another costly alternative. We offer naturally isolated melittin made from bee venom that is accomplished in our own laboratory using an effective method what we have developed ourselves. Please inform us of your requirements.
The melittin which we put up shows a purity over 95% and is almost completely separated from the allergens PLA2 and hyaluronidase.
APAMIN
Peptide
Apamin is a 2111.4 Da weighty peptide, which is assembled of 18 amino acids, forming two disulfate bridges with a proportion of 1-3% in the bee venom. It is interesting that it can cross the blood-barrier and thus find access to the central nervous system.
In addition to the anti-inflammatory effect, research was also carried out in different fields relating to the central nervous system.
We are happy to provide you with apamin isolated from raw bee venom with high degree of purity.
PLA2
Peptide
The enzyme phospholipase A2 or Api m1 is a polypeptide consisting of 134 amino acids and weighing 15-18 kDa. The stability of the enzyme is due to the 5 disulfide bridges.
There is a broad variety of PLA2 in nature, so these enzymes are divided into 16 groups. PLA2, which is derived from the bee (bPLA2), belongs to group III, which shows a strong Ca dependence.
Besides the antibacterial and antiviral properties, a high cytotoxic activity against cancer cells has been proven repeatedly.
Purchase this enzyme directly from us.
APITHERAPY
Bee venom therapy
In a special application method of traditional Asian medicine knowing as pharmacopuncture, bee venom is applied under the skin using acupuncture needles. In certain countries such as South Korea, good results have already been achieved in the treatment of inflammatory skin diseases, rheumatoid arthritis, and multiple sclerosis. This can be explained on the one hand by local effects such as reduced inflammation. On the other hand, by mechanical effects such as the activation of cortisol production by stimulating the adrenocorticotropic hormones from the pituitary gland.